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Publications

BioServe Publications and Presentations

Here is a sampling of recent academic poster presentations by BioServe researchers:

Fish and Dairy Consumption and reduced risk of breast Cancer

Diet is a modifiable risk factor for cancer. Previous studies examining the association between diet and breast cancer have shown variable results. The present study examines the relationship between dietary intake of fish and dairy products and breast cancer risk in a large nested case-control study.

Obesity and Type II Diabetes Risk; A Multinational Study

This study examines the association between obesity and risk of type II diabetes (T2D) in a large multiethnic observational study. We examined effect modification of the obesity-T2D association by race and physical activity.
The present study also examines the relationship between genotypes and T2D risk in a nested case-control study.

Obesity Diet and Type II Diabetes Risk

Many studies have shown that obesity is associated with risk of type II diabetes. However there are inconsistencies in many areas that need to be resolved. Areas of particular interest include further analyses of effect modification by race, gender, smoking and exercise.

Exercise and Reduced Breast Cancer Risk; A Multinational Study

Many studies have shown that physical activity is associated with reduced risk of breast cancer. However there are inconsistencies in many areas that need to be resolved (Sprague et.al., 2007). Areas of particular interest include further analyses of effect modification by race, menopausal status and cancer characteristics such as receptor status and node involvement.
The present study examines the relationship between recreational physical activity and breast cancer risk in a population based case-control study.

Date Title
2010 Bhatia K, Modali R, Goedert JJ. Merkel cell polyomavirus is not detected in mesotheliomas. J Clin Virol. 2010 Feb;47(2):196-8. Epub 2009 Dec 16.
2009 Murphy G, Cross AJ, Sansbury LS, Bergen A, Laiyemo AO, Albert PS, Wang Z, Yu B, Lehman T, Kalidindi A, Modali R, Schatzkin A, Lanza E. Dopamine D2 receptor polymorphisms and adenoma recurrence in the Polyp Prevention Trial. Int J Cancer. 2009 May 1;124(9):2148-51.
2009 Bhatia K, Goedert JJ, Modali R, Preiss L, Ayers LW. Merkel cell carcinoma subgroups by Merkel cell polyomavirus DNA relative abundance and oncogene expression. Int J Cancer. 2009 Jun 23;126(9):2240-2246.
2009 Bhatia K, Goedert JJ, Modali R, Preiss L, Ayers LW. Immunological detection of viral large T antigen identifies a subset of Merkel cell carcinoma tumors with higher viral abundance and better clinical outcome. Int J Cancer. 2009 Dec 29.
2008 Murphy G, Sansbury LS, Bergen AW, Wang Z, Schatzkin A, Lehman T, Kalidindi A, Modali R, Lanza E. Polynucleotide kinase 3′ phosphatase variant, dietary variables and risk of adenoma recurrence in the Polyp Prevention Trial. Eur J Cancer Prev. 2008 Jun;17(3):287-90.
2008 Quick Sylvia K; Shields Peter G; Nie Jing; Platek Mary E; McCann Susan E; Hutson Alan D; Trevisan Maurizio; Vito Dominica; Modali Ramakrishna; Lehman Teresa A; Seddon Mike; Edge Stephen B; Marian Catalin; Muti Paola; Freudenheim Jo L. Effect modification by catalase genotype suggests a role for oxidative stress in the association of hormone replacement therapy with postmenopausal breast cancer risk. Cancer epidemiology, biomarkers & prevention: a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2008;17(5):1082-7.
2008 Murphy G, Sansbury LB, Cross AJ, Stolzenberg-Solomon R, Laiyemo A, Albert PS, Wang Z, Schatzkin A, Lehman T, Kalidindi A, Modali R, Lanza E. Folate and MTHFR: risk of adenoma recurrence in the Polyp Prevention Trial. Cancer Causes Control. 2008 Sep;19(7):751-8. Epub 2008 Mar 6.
2006 Sansbury, L.B., Bergen, A.W., Wanke, K.L., Yu, B., Caporaso, N.E., Chatterjee, N., Ratnasinghe, L., Schatzkin, A., Lehman, T.A., Kalidindi, A., Modali, R., Lanza, E. Inflammatory cytokine gene polymorphisms, nonsteroidal anti-inflammatory drug use, and risk of adenoma polyp recurrence in the polyp prevention trial. Cancer Epidemiol Biomarkers Prev. 2006 Mar;15(3):494-501.

2006 Gaudet, M.M., Bensen, J.T., Schroeder, J., Olshan, A.F., Terry, M.B., Eng, S.M., Teitelbaum, S.L., Britton, J.A., Lehman, T.A., Neugut, A.I., Ambrosone, C.B., Santella, R.M., Gammon, M.D. Catechol-O-methyltransferase haplotypes and breast cancer among women on Long Island, New York. Breast Cancer Res Treat. 2006 Apr 5; [Epub ahead of print].
2005 Lin, T.S., Flinn, I.W., Modali, R., Lehman, T.A., Webb, J., Waymer, S., Moran, M.E., Lucas, M.S., Sherif, F.S., Byrd, J.C. FcRI{gamma}IIa and FcR{gamma}IIa Polymorphisms May Not Correlate with Response to Alemtuzumab (Campath-1H) in Chronic Lymphocytic Leukemia (CLL). Blood 105: 289-291, 2005.

2005 Stone A, Ratnasinghe LD, Emerson GL, Modali R, Lehman T, Runnells G, Carroll A, Carter W, Barnhart S, Rasheed AA, Greene G, Johnson DE, Ambrosone CB, Kadlubar FF, Lang NP. CYP3A43 Pro(340)Ala polymorphism and prostate cancer risk in African Americans and Caucasians. Cancer Epidemiol Biomarkers Prev. 2005 May;14(5):1257-61.
2004 Farag, S.S., Flinn, I.W., Modali, R., Lehman, T.A., Byrd, J.C. Fc(gamma)RIIIa and Fc(gamma)RIIa polymorphisms do not predict response to rituximab in B-cell chronic lymphatic leukemia. Blood 103: 1472-1474, 2004.

2003 Kamel, F., Umbach, D.M., Lehman, T.A., Park, L.P., Munsat, T.L., Shefner, J.M., Sandler, D.P., Hu, H., Taylor J.A. Amyotrophic lateral sclerosis, lead, and genetic susceptibility: polymorphisms in the delta-aminolevulinic acid dehydratase and vitamin D receptor genes. Environ Health Perspect. 111: 1335-9, 2003.

2003 Martinez, A., Lehman, T.A. Modali, R., Mulshine, J.L. The ras family of oncogenes in development and progression of lung cancer. Screening of mutations by polymerase chain reaction-based ligase chain reaction. Methods Mol Med. 74:187-200, 2003.
2003 Woodson, K., Tangrea, J.A., Lehman, T.A., Modali, R., Taylor, K.M., Snyder, K., Taylor, P.R., Virtamo, J., Albanes, D. Manganese superoxide dismutase (MnSOD) polymorphism, alpha-tocopherol supplementation and prostate cancer risk in the alpha-tocopherol, beta-carotene cancer prevention study (Finland). Cancer Causes Control. 14: 513-518, 2003.

2001 Byrd, J.C., Shinn, C., Willis, C.R., Flinn, I.W., Lehman, T., Sausville, E., Lucas, D., Grever, M.R. UCN-01 induces cytotoxicity toward human CLL cells through a p53 independent mechanism. Exp Hematol 29 (6) 703-708, 2001.

2001 London, S., Xia, J., Lehman, T., Yang, J.H., Granada, E., Chunhong, L., Dubeau, L, Li, T., David-Beabes, G., Li, Y. Collection of buccal cell DNA in seventh-grade children using water and a toothbrush. Cancer Epidemiology, Biomarkers and Prevention 10: 1227-1230, 2001.

2000 Lehman, T.A., Haffty, B.G., Carbone, C.J., Bishop, L.R., Gumbs, A.A., Krishnan, S., Shields, P.G., Modali, R., Turner, B.C. Elevated frequency and functional activity of a specific germ-line p53 intron mutation in familial breast cancer. Cancer Res. 60:1062-1069, 2000.
1999 Berger, D.H., Chang, H., Wood, M., Huang, L., Heath, C.W., Lehman, T., Ruggeri, B.A. Mutational activation of K-ras in nonneoplastic exocrine pancreatic lesions in relation to cigarette smoking status. Cancer 85: 326-329, 1999.

1999 Panguluri R C; Brody L C; Modali R; Utley K; Adams-Campbell L; Day A A; Whitfield-Broome C; Dunston G M. BRCA1 mutations in African Americans. Human genetics 1999;105(1-2):28-31.
1998 Byrd, J.C., Shinn, C., Waselenko, J.K., Fuchs, E.J., Lehman, T.A., Nguyen, P.L., Flinn, I.W., Diehl, L.F., Sausville, E., Grever, M.R. Flavopiridol induces apoptosis in chronic lymphocytic leukemia cells via activation of caspase-3 without evidence of bcl-2 modulation or dependence on functional p53. Blood 92:3804-16, 1998.

1997 London, S.J., Lehman, T.A., and Taylor, J.A. Myeloperoxidase genetic polymorphism and lung cancer risk. Cancer Res. 57: 5001-5003, 1997.
1997 Scott, F., Modali, R., Lehman, T.A., Seddon, M., Kelly, K., Dempsey, E.C., Wilson, V., Tockman, M.S., and Mulshine, J.L. High frequency of K-ras mutations in bronchial alveolar lavage fluid of patients at high risk for second primary lung cancer. Clin. Cancer Res. 3: 479-482, 1997.

1997 Gopalakrishnan, R., Weghorst, C.M., Lehman, T.A., Bijur, G., Sabourin, C.L.K., Mallery, S.R., and Stoner, G.D. p53 expression and HPV in proliferative verrucous leukoplakia. Oral Surgery, Oral Med., Oral Path., Oral Rad., and Endodontics. 83: 471-477, 1997.

1997 Caloca, M.J., Fernandez, N., Lewin, N.E., Ching, D., Modali, R., Blumburg, P.M., Kazanietz, M.G. Beta2-chimaerin is a high affinity receptor for the phorbol ester tumor promoters. J. Biol. Chem. 272: 26488-26496, 1997.
1996 Ohnuki, Y., Reddel, R., Bates, S.E., Lehman, T.A., et al. Chromosomal changes and progressive tumorigenesis of human bronchial epithelial cell lines. Cancer Genet. Cytogenet. 92: 99-110, 1996.
1996 Lehman, T.A., Scott, F., Seddon, M., Kelly, K., Dempsey, E.C., Wilson, V.L., Mulshine, J.L., and Modali, R. Detection of K-ras oncogene mutations by polymerase chain reaction-based ligase chain reaction. Anal. Biochem. 239: 153-159, 1996.

1995 Harris, C., Pfeifer, A., Lehman, T., Weston, A., Gerwin, B. and Lechner, J.: Oncogenes and tumor suppressor genes in human carcinogenesis. Cancer Res. Clin. Oncol.
1995 Speir, E., Huang, E.S., Modali, R., Leon, M.B., Interaction of human cytomegalovirus with p53: possible role in coronary restenosis. Scand. J. Infect. Dis. Suppl., 99: 78-81, 1995.
1994 Speir, E., Modali, R., Leon, M., Shawl, F., Guzman, R., Finkel, T., Huang, E. S., Griner, J., Choi, B., and Epstein, S. E. Evidence suggesting a causal role of human cytomegalovirus in coronary restinosis: interaction with the tumor suppressor gene p53. Science 265: 391-394, 1994.
1994 Lehman, T. A. and Harris, C. C.: Mutational spectra of protooncogenes and tumor suppressor genes: clues to predict cancer etiology. IARC Monograph. Vol. 125, Lyon, France, 1994, pp. 399-412.
1994 Lehman, T. A., Greenblatt, M., Bennett, W. P. and Harris, C. C.: Mutational spectrum of the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis. Drug Metabol. Rev. 26: 221-235, 1994.
1994 Hollstein, M., Marion, M.-J., Lehman, T., Welsh, J., Harris, C. C., Kusters, I., and Montesano, R.: p53 mutations at A:T base pairs in angiosarcomas of vinyl chloride-exposed factory workers. Carcinogenesis. 15: 1-3, 1994.
1993 Lehman, T.A., Modali, R., Stanek, J., Welsh, J., Bennett W. P., Stampfer, M., Boukamp, P., Fusenig, N., Rogan, E. M., Reddel, R. R. and Harris, C.C. p53 mutations in human immortalized epithelial cell lines. Carcinogenesis 14:833-839, 1993.
1993 Esteve, A., Lehman, T., Jiang, W., Weinstein, I. B., Harris, C. C., Ruol, A., Peracchia, A., Montesano, R. and Hollstein, M.: Correlation of p53 mutations with epidermal growth factor receptor overexpression and absence of mdm2 amplification in human esophageal carcinomas. Mol. Carcinog. 8: 306-311, 1993.
1992 Metcalf, R. A., Welsh, J. A., Bennett, W.P., Lehman, T. A., Pelin, K., Linnainmaa, K., Tammilehto, L., Mattson, K., Gerwin, B. I., and Harris, C. C.: p53 and Kirsten-ras mutations in human mesothelioma cell lines. Cancer Res. 52:2610-2615, 1992.
1992 Cajot, J.-F., Anderson, M. J., Lehman, T. A., Shapiro, H., Briggs, A. A. and Stanbridge, E. J.: Growth suppression mediated by transfection of p53 in Hut292DM human lung cancer cells expressing endogenous wild-type p53 protein. Cancer Res. 52:6956-6960, 1992.
1992 Lehman, T. A. and Harris, C. C.: Oncogene and tumor suppressor gene involvement in human lung carcinogenesis. Transformation of Human Epithelial Cells: Molecular and Oncogenetic Mechanisms, CRC Press, Florida, 1992, pp. 235-259.
1992 Gerwin, B.I., Spillare, E., Forrester, K., Lehman, T.A., Kispert, J., Welsh, J.A., Pfeifer, A.M.A., Lechner, J.F., Baker, S.J., Vogelstein, B., and Harris, C.C.: Mutant p53 can induce tumorigenic conversion of human bronchial epithelial cells and reduce their responsiveness to a negative growth factor, transforming growth factor type 1. Proc. Natl. Acad. Sci. USA. 89: 2759-2763, 1992.
1991 Harris, C. C., Bennett, W. P., Gerwin, B. I., Iman, D. S., Lehman, T. A., Metcalf, R. A., Pfeifer, A. M. A., Reddel, R. R., Sugimura, H. and Weston, A.: Oncogenes and tumor suppressor genes involved in human lung carcinogenesis. In Brugge, J., Curran, T., Harlow, E. and McCormick, F. (Eds.): Origins of Human Cancer, Cold Spring Harbor Laboratory Press, New York, 1991, pp. 739-744.
1991 Lehman, T. A., Pfiefer, A. M. A., Metcalf, R. A., Bennett, W. P., Weston, A., Gerwin, B. I., and Harris, C. C.: Oncogenes and tumor suppressor genes in human lung carcinogenesis. In: Waxman, S. (Ed.) Second Volume on Differentiation Therapy. Raven Press, New York, 1991, pp. 87-98.
1991 Lehman, T. A., Bennett, W. P., Metcalf, R. A., Reddel, R., Welsh, J. A., Ecker, J., Modali, R. V., Ullrich, S., Romano, J. W., Appella, E., Testa, J. R., Gerwin, B. I., Harris, C. C.: p53 mutations, ras mutations and p53-heat shock 70 protein complexes in human lung cell lines. Cancer Res. 51: 4090-4096, 1991.

1991 Lehman, T. A., Reddel, R. R., Pfeifer, A. M. A., Spillare, E., Kaighn, M. E., Weston, A., Gerwin, B. I. and Harris, C. C.: Oncogenes and tumor suppressor genes. Environ. Health Perspect. 93: 133-144, 1991.

1991 Lehman, T. A., and Harris, C. C. Neoplastic transformation and suppression of transformation of human bronchial epithelial cells in vitro. In Rhim, J.S. and Dritschilo A. (Eds.): Neoplastic Transformation in Human Cell Culture, The Humana Press, Inc., New Jersey. 1991, pp.251-258.
1990 Harris, C. C., Reddel, R., Modali, R., Lehman, T. A., Iman, D., McMenamin, M., Sugimura, H., Weston, A. and Pfeifer, A.: Oncogenes and tumor suppressor genes involved in human lung carcinogenesis. In Sutherland, B. M. and Woodhead, A. D. (Eds.): DNA Damage and Repair in Human Tissues, New York, Plenum Press, 1990, pp. 363-380.
1990 Harris, C. C., Reddel, R., Pfeifer, A., Amstad, P., Mark, G., Weston, A., Modali, R., Iman, D., McMenamin, M., Kaighn, E., Gabrielson, E., Jones, R. and Trump, B. F.: Oncogenes and tumor suppressor genes in human lung carcinogenesis. In Harris, C. C. and Liotta, L. (Eds.): Genetic Mechanisms in Carcinogenesis and Tumor Progression, New York, Wiley-Liss, 1990, pp 127-152.
1990 Sugimura, H., Caporaso, N.E., Shaw, G.L., Modali, R.V., Gonzalez, F.J., Hoover, R.N., Resau, J.H., Trump, B.F., Weston, A. and Harris, C.C. : Human debrisoquine hydroxy┬Člase gene polymorphisms in cancer patients and controls. Carcinogenesis 11: 1527-1530, 1990.
1990 Sugimura, H., Caporaso, N. E., Hoover, R. N., Modali, R., Resau, J., Trump, B. F., Lonergan, J. A., Krontiris, T. G., Mann, D. L., Weston, A. and Harris, C. C.: Association of rare alleles of the Ha-ras-1 locus with lung cancer. Cancer Res. 50: 1857-1862, 1990.
1990 Weston, A., Sugimura, H., Modali, R., Bowman, E.D., Caporaso, N.E., Manchester, D. K., Shields, P. G., Poirier, M. C. and Harris, C. C.: Molecular dosimetry, genetic susceptibility and cancer risk. In Volans, G. N., Sims, J., Sullivan, F.M. and Turner, P. (Eds.): Basic Science Proceedings of the V International Congress of Toxicology, Philadelphia, Taylor and Francis, Ltd., 1990, pp. 263-279.
1989 Nigro, J. M., Baker, S. J., Preisinger, A. C., Jessup, J. M., Hostetter, R., Cleary, K., Bigner, S. H., Davidson, N., Baylin, S., Devilee, P., Glover, T., Weston, A., Modali, R., Harris, C. C. and Vogelstein, B.: p53 gene mutations occur in diverse human tumor types. Nature, 342: 705-708, 1989.
1989 Weston, A., Willey, J. C., Modali, R., Sugimura, H., McDowell, E., Resau, J., Light, B., Haugen, A., Mann, D. L., Trump, B. F. and Harris, C. C.: Differential DNA sequence deletions from chromosomes 3, 11, 13 and 17 in squamous cell carcinoma, large cell carcinoma and adenocarcinoma of the human lung. Proc. Natl. Acad. Sci. USA, 86: 5099-5103, 1989.
1989 Kumari, H. L., Shuler, C. F., Lehman, T., Ferrone, S. and Milo, G. E.: Development of neoplastic phenotype following transfection of HNF cell with sarcoma DNA. Carcinogenesis, 10: 401-404, 1989.
1989 Milo, G. E., Yohn, J., Schuller, D., Noyes, I. and Lehman, T.: Comparative stages of expression of human squamous carcinoma cells. J. Invest. Dermatol., 92: 848-853, 1989.

1989 Lehman, T., Kurian, P. and Milo, G. E.: Metabolism of and DNA adduct formation by benzo[a]pyrene in human skin epithelial cells in vitro pretreated with cytochrome P450 modulators. Cancer Biochem. Biophys., 10: 345-352, 1989.
1988 Yohn, J., Lehman, T. A., Kurian, P., Ribovich, M. and Milo, G.E.: Benzo[a]pyrene diol epoxide I modification of DNA in human skin xenografts. J. Invest. Dermatol., 91: 363-368, 1988.

1988 Stoner, G. D., Shivapurkar, N. M., Schut, H. A. J. and Lehman, T.: DNA binding and adduct formation of 4,4-methylene-bis(2-chloroainline) (MOCA) in explant cultures of human and dog bladder. Cancer Lett., 39: 237-240, 1988.
1988 Milo, G. E., Oldham, J. W., Noyes, I., Lehman, T. A., Kumari, H. L., West, R. W. and Kadlubar, F. F.: Cocarcinogenicity of saccharin and N-alkyl-nitrosoureas in cultured diploid human fibroblasts. J. Toxicol. Envirn. Health, 24: 413-421, 1988.
1988 Yang, S. S., Modali, R., Park, J. B. and Taub, J. V.: Transforming DNA sequences of human hepatocellular carcinomas, their distribution and relationship with hepatitis B virus sequence in human hepatomas. Leukemia, 2: 102s-113s, 1988.
1987 Shivapurkar, N., Lehman, T., Schut, H. A. J. and Stoner, G. D.: DNA binding of 4,4′-methylene-bis(2-chloroainline) (MOCA) in explant cultures of human and dog bladder. Cancer Lett., 38: 41-48, 1987.

1986 Lehman, T., Noyes, I. and Milo, G. E.: Establishment and chemical and transformation of human skin epithelial cells in vitro. J. Tissue Culture Methods, 10: 197-203, 1986.
1986 Modali, R. and Yang, S. S.: Specificity of aflatoxin B1 binding on human proto-oncogene nucleotide sequence. Prog. Clin. Biol. Res., 207: 147-158, 1986.
1985 Yang, S. S., Taub, J. V., Modali, R., Vieira, W., Yasei, P. and Yang, G. C.: Dose dependency of aflatoxin B1 binding on human high molecular weight DNA in the activation of proto-oncogenes. Environ. Health Perspect., 62: 231-238, 1985.
1984 NULLYang, S. S., Modali, R. and Yang, G. C.: Formation of aflatoxin B1-DNA adducts in normal rat and hepatoma tissue culture cells and in human livers from fetal, Reye’s syndrome and hepatocellular carcinoma. Advances in Gene Technology: Human Genetic Disorders, In: Ahmad, F., Black, S., Schultz, J., Scott, W. A. and Whelan, W. J. (Eds.), ICSU Press, Florida, pp. 272-273, 1984.
1984 Yang, S. S., Modali, R. and Murphy, E., Jr.: Cloning of the rat endogenous helper leukemia virus DNA sequence and expression of the helper activity encoded by the cloned DNA sequence in normal rat kidney cells by micro-injection. Eucaryotic Cell Culture: Basic and Application. Advances in Experimental Medicine and Biology, 172, In: Acton, R. and Lynn, J. D. (Eds.), Plenum Press, New York, pp. 295-319, 1984.
1983 Yang, S. S. and Modali, R.: An analysis of the genomic complexity of the cloned wild rat endogenous retrovirus (WR-RaLV) DNA. Leukemia Rev., 1: 310-312, 1983.
1982 Yang, S. S., Taub, J., Modali, R. and Gardner, M.: Molecular cloning of the rat leukemia-helper virus DNA sequences and functional analysis of some restricted DNA fragments. Advances in Comparative Leukemia Research 1981, In: Yohn, D. S. and Blakeslee, J. R. (Eds.), Elsevier/North-Holland Biomedical Press, pp. 351-352, 1982.
1982 Yang, S. S., Modali, R., Wu, R. and Gardner, M.: Molecular cloning of the endogenous rat C-type helper virus DNA sequence: Structural organization and functional analysis of some restricted DNA fragments. J. Gen. Virol., 63: 25-36, 1982.
1982 Yang, S. S., Taub, J., Modali, R., Brown, D. and Murphy, E., Jr.: Biological activity of cloned rat endogenous C-type viral DNA transferred by microinjection. J. Gen. Virol., 63: 37-43, 1982.
1982 Yang, S. S. and Modali, R.: Genomic complexity and molecularly cloning of a proviral DNA specific for a feral rat endogenous C-type virus, originated from a 3-methyl cholanthrene induced fibrosarcoma. Progress in Nucleic Acid Research and Molecular Biology, Vol. 29, In: Cohn, W. (Ed.), Academic Press, New York, pp. 145-149, 1982.

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